Transcriptional Network Controlling Endochondral Ossification

Achondroplasia: Development, pathogenesis, and therapy.

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy.

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.

The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.

Transcriptional Network Controlling Endochondral Ossification

Regulation of Cartilage Development and Diseases by Transcription Factors

Achondroplasia: Development, pathogenesis, and therapy.

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy.

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.

The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.

Development of the endochondral skeleton

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.

Transcriptional Network Controlling Endochondral Ossification

Regulation of Cartilage Development and Diseases by Transcription Factors

Achondroplasia: Development, pathogenesis, and therapy.

AP-1 family members act with Sox9 to promote chondrocyte hypertrophy.

Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte.

The transcription factor Foxc1 is necessary for Ihh-Gli2-regulated endochondral ossification.

The transcription factors SOX9 and SOX5/SOX6 cooperate genome-wide through super-enhancers to drive chondrogenesis.

Arid5b facilitates chondrogenesis by recruiting the histone demethylase Phf2 to Sox9-regulated genes.

Development of the endochondral skeleton

Multiple Phases of Chondrocyte Enlargement Underlie Differences in Skeletal Proportions

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes.

FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program.