Transcriptional Mechanisms Underlying Lymphocyte Tolerance

  title={Transcriptional Mechanisms Underlying Lymphocyte Tolerance},
  author={Fernando Macian and Francisco Garcı́a-C{\'o}zar and Sin-Hyeog Im and Heidi F. Horton and Michael C. Byrne and Anjana Rao},
In lymphocytes, integration of Ca2+ and other signaling pathways results in productive activation, while unopposed Ca2+ signaling leads to tolerance or anergy. We show that the Ca2+-regulated transcription factor NFAT has an integral role in both aspects of lymphocyte function. Ca2+/calcineurin signaling induces a limited set of anergy-associated genes, distinct from genes induced in the productive immune response; these genes are upregulated in vivo in tolerant T cells and are largely NFAT… CONTINUE READING
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