Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution

  title={Transcriptional Maps of 10 Human Chromosomes at 5-Nucleotide Resolution},
  author={J. Cheng and P. Kapranov and J. Drenkow and S. Dike and S. Brubaker and S. Patel and J. Long and D. Stern and H. Tammana and G. Helt and V. Sementchenko and A. Piccolboni and S. Bekiranov and D. Bailey and M. Ganesh and S. Ghosh and I. Bell and D. Gerhard and T. Gingeras},
  pages={1149 - 1154}
  • J. Cheng, P. Kapranov, +16 authors T. Gingeras
  • Published 2005
  • Biology, Medicine
  • Science
  • Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human chromosomes were mapped at 5–base pair resolution in eight cell lines. Unannotated, nonpolyadenylated transcripts comprise the major proportion of the transcriptional output of the human genome. Of all transcribed sequences, 19.4, 43.7, and 36.9% were observed to be polyadenylated, nonpolyadenylated, and bimorphic, respectively. Half of all transcribed sequences are found only in the nucleus and for the most part… CONTINUE READING
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