Transcriptional Feedback of Neurospora Circadian Clock Gene by Phosphorylation-Dependent Inactivation of Its Transcription Factor

@article{Schafmeier2005TranscriptionalFO,
  title={Transcriptional Feedback of Neurospora Circadian Clock Gene by Phosphorylation-Dependent Inactivation of Its Transcription Factor},
  author={Tobias Schafmeier and Andrea Haase and Krisztina K{\'a}ldi and Johanna Scholz and Marc Fuchs and Michael Brunner},
  journal={Cell},
  year={2005},
  volume={122},
  pages={235-246}
}
The circadian clock protein Frequency (FRQ) feedback-regulates its own expression by inhibiting its transcriptional activator, White Collar Complex (WCC). We present evidence that FRQ regulates the bulk of WCC through modulation of its phosphorylation status rather than via direct complex formation. In the absence of FRQ, WCC is hypophosphorylated and transcriptionally active, while WCC is hyperphosphorylated and transcriptionally inactive when FRQ is expressed. The phosphorylation status of… CONTINUE READING
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