Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease

  title={Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease},
  author={Patrick M. Flood and Li Qian and Lynda Peterson and F. Y. Zhang and Jing-Shan Shi and Hui-ming Gao and Jau-Shyong Hong},
  booktitle={Parkinson's disease},
Parkinson's disease (PD) is a neurodegenerative condition characterized by chronic inflammation. Nuclear factor κB (NF-κB) is a family of inducible transcription factors that are expressed in a wide variety of cells and tissues, including microglia, astrocytes, and neurons, and the classical NF-κB pathway plays a key role in the activation and regulation of inflammatory mediator production during inflammation. Activation of the classical NF-κB pathway is mediated through the activity of the IKK… CONTINUE READING
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