Transcriptional Dysregulation in Postnatal Glutamatergic Progenitors Contributes to Closure of the Cortical Neurogenic Period.

@article{Donega2018TranscriptionalDI,
  title={Transcriptional Dysregulation in Postnatal Glutamatergic Progenitors Contributes to Closure of the Cortical Neurogenic Period.},
  author={Vanessa Donega and Guillaume Marcy and Quentin Lo Giudice and Stefan Zweifel and Diane Angonin and Roberto Fiorelli and Djoher Nora Abrous and Sylvie Rival-Gervier and Muriel Koehl and Denis Jabaudon and Olivier Raineteau},
  journal={Cell reports},
  year={2018},
  volume={22 10},
  pages={
          2567-2574
        }
}
Progenitors of cortical glutamatergic neurons (Glu progenitors) are usually thought to switch fate before birth to produce astrocytes. We used fate-mapping approaches to show that a large fraction of Glu progenitors persist in the postnatal forebrain after closure of the cortical neurogenesis period. Postnatal Glu progenitors do not accumulate during embryonal development but are produced by embryonal radial glial cells that persist after birth in the dorsal subventricular zone and continue to… CONTINUE READING
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