Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein

@article{He2015TranscriptionalCO,
  title={Transcriptional Control of Synaptic Remodeling through Regulated Expression of an Immunoglobulin Superfamily Protein},
  author={Siwei He and Alison Philbrook and Rebecca D. McWhirter and Christopher V Gabel and Daniel G Taub and Maximilian H. Carter and Isabella M. Hanna and Michael M Francis and David M. Miller},
  journal={Current Biology},
  year={2015},
  volume={25},
  pages={2541-2548}
}
Neural circuits are actively remodeled during brain development, but the molecular mechanisms that trigger circuit refinement are poorly understood. Here, we describe a transcriptional program in C. elegans that regulates expression of an Ig domain protein, OIG-1, to control the timing of synaptic remodeling. DD GABAergic neurons reverse polarity during larval development by exchanging the locations of pre- and postsynaptic components. In newly born larvae, DDs receive cholinergic inputs in the… CONTINUE READING
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