Transcriptional Control of Left–Right Patterning in Cardiac Development

@article{Chen2009TranscriptionalCO,
  title={Transcriptional Control of Left–Right Patterning in Cardiac Development},
  author={Chiann-Mun Chen and Dominic P Norris and Shoumo Bhattacharya},
  journal={Pediatric Cardiology},
  year={2009},
  volume={31},
  pages={371-377}
}
The heart develops from a simple left–right (L–R) symmetrical tube. Through a complex process of looping and remodelling, it becomes a highly L–R asymmetrical organ with distinct asymmetries in both morphology and function. Abnormal cardiac L–R patterning can result in a spectrum of defects that include, dextrocardia (a malposition of the heart to the right), isomerism of the atria (both atria being morphologically right-sided or left-sided), abnormal ventricular topology (e.g. the… 
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Analysis of the tendrils of climbing plants disclosed striking resemblance between the configurations of embryonic heart loops and a form motif named helical perversion, which may be the best geometrical solution of the form problem of embryonicHeart loops.
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References

SHOWING 1-10 OF 81 REFERENCES
Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination.
TLDR
The purpose of this review is to highlight what is presently known about cardiac development and upstream processes of left-right axis determination, and to consider how perturbation of the left- right body plan might ultimately result in particular types of congenital heart defects.
Cited2 is required both for heart morphogenesis and establishment of the left-right axis in mouse development
TLDR
It is proposed that, in addition to the previously described reduction of cardiac neural crest cells, two other distinct mechanisms contribute to the spectrum of complex cardiac defects in Cited2-null mice; disruption of normal left-right patterning and direct loss of Citation2 expression in cardiac tissues.
A role of the cryptic gene in the correct establishment of the left–right axis
TLDR
The results provide genetic evidence for a role of cryptic in the signalling cascade that determines left-right asymmetry in vertebrate embryogenesis.
Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway
TLDR
It is proposed that an abnormal Nodal-Pitx2c pathway represents a unifying mechanism for the cardiovascular malformations observed in Cited2−/− mice, and that such mal Formations may be the sole manifestation of a laterality defect.
The role of Pitx2 during cardiac development. Linking left-right signaling and congenital heart diseases.
TLDR
Current studies suggest that altered left-right signaling underlies the etiology of several common congenital cardiac malformations.
Node and midline defects are associated with left-right development in Delta1 mutant embryos
TLDR
It is reported that Notch signalling, which previously had not been implicated in this morphogenetic process, is required for normal left-right determination in mice, and suggested a model, in which Notch signals are required for the proper differentiation of node cells and node morphology.
Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation.
TLDR
It is proposed that a signaling pathway mediated by Nodal and EGF-CFC activities is essential for transfer of L-R positional information from the node.
Myocardial Pitx2 Differentially Regulates the Left Atrial Identity and Ventricular Asymmetric Remodeling Programs
TLDR
In situ hybridization analysis and genetic analysis show that myocardial Pitx2 expression delineates the remodeling of the left atrioventricular canal, the inner curvature, the ventral part of the interventricular ring, and the ventrals portion of the right and left ventricle in mouse heart development.
Smad5 is essential for left-right asymmetry in mice.
TLDR
It is demonstrated that Smad5 mutant embryos have defects in heart looping and embryonic turning which are the first signs of L-R asymmetry in mice, and data suggest thatSmad5 is upstream oflefty-1, nodal, and lefty- 2, and as a consequence also of Pitx2, and Smad 5 is essential for L- R axis determination.
Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch
TLDR
The results indicate that haemodynamics, generated by a Pitx2-induced morphological change in the outflow tract, is responsible for the asymmetric remodelling of the great arteries.
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3
4
5
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