Transcriptional Bursting in Gene Expression: Analytical Results for General Stochastic Models

@article{Kumar2015TranscriptionalBI,
  title={Transcriptional Bursting in Gene Expression: Analytical Results for General Stochastic Models},
  author={Niraj Kumar and Abhyudai Singh and Rahul V. Kulkarni},
  journal={PLoS Computational Biology},
  year={2015},
  volume={11}
}
Gene expression in individual cells is highly variable and sporadic, often resulting in the synthesis of mRNAs and proteins in bursts. Such bursting has important consequences for cell-fate decisions in diverse processes ranging from HIV-1 viral infections to stem-cell differentiation. It is generally assumed that bursts are geometrically distributed and that they arrive according to a Poisson process. On the other hand, recent single-cell experiments provide evidence for complex burst arrival… 
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