Transcriptional Analysis of Hair Follicle-Derived Keratinocytes from Donors with Atopic Dermatitis Reveals Enhanced Induction of IL32 Gene by IFN-γ

@inproceedings{Yoshikawa2013TranscriptionalAO,
  title={Transcriptional Analysis of Hair Follicle-Derived Keratinocytes from Donors with Atopic Dermatitis Reveals Enhanced Induction of IL32 Gene by IFN-γ},
  author={Yoshie Yoshikawa and Yusuke Sasahara and Katsuyuki Takeuchi and Yoshimasa Tsujimoto and Takashi Hashida-Okado and Yukio Kitano and Tomoko Hashimoto-Tamaoki},
  booktitle={International journal of molecular sciences},
  year={2013}
}
We cultured human hair follicle-derived keratinocytes (FDKs) from plucked hairs. To gain insight into gene expression signatures that can distinguish atopic dermatitis from non-atopic controls without skin biopsies, we undertook a comparative study of gene expression in FDKs from adult donors with atopic dermatitis and non-atopic donors. FDK primary cultures (atopic dermatitis, n = 11; non-atopic controls, n = 7) before and after interferon gamma (IFN-γ) treatment were used for microarray… CONTINUE READING

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