Transcriptional Activity among High and Low Risk Human Papillomavirus E2 Proteins Correlates with E2 DNA Binding*

@article{Hou2002TranscriptionalAA,
  title={Transcriptional Activity among High and Low Risk Human Papillomavirus E2 Proteins Correlates with E2 DNA Binding*},
  author={Samuel Y. Hou and Shwu‐Yuan Wu and Cheng Ming Chiang},
  journal={The Journal of Biological Chemistry},
  year={2002},
  volume={277},
  pages={45619 - 45629}
}
The full-length E2 protein, encoded by human papillomaviruses (HPVs), is a sequence-specific transcription factor found in all HPVs, including cancer-causing high risk HPV types 16 and 18 and wart-inducing low risk HPV types 6 and 11. To investigate whether E2 proteins encoded by high risk HPVs may function differentially from E2 proteins encoded by low risk HPVs and animal papillomaviruses, we conducted comparative DNA-binding and transcription studies using electrophoretic mobility shift… Expand
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