Transcription through the roadblocks: the role of RNA polymerase cooperation.

@article{Epshtein2003TranscriptionTT,
  title={Transcription through the roadblocks: the role of RNA polymerase cooperation.},
  author={Vitaly Epshtein and Francine Toulm{\'e} and Abdelkader Rahmouni and Sergei Borukhov and Vladimir Svetlov},
  journal={The EMBO journal},
  year={2003},
  volume={22 18},
  pages={
          4719-27
        }
}
During transcription, cellular RNA polymerases (RNAP) have to deal with numerous potential roadblocks imposed by various DNA binding proteins. Many such proteins partially or completely interrupt a single round of RNA chain elongation in vitro. Here we demonstrate that Escherichia coli RNAP can effectively read through the site-specific DNA-binding proteins in vitro and in vivo if more than one RNAP molecule is allowed to initiate from the same promoter. The anti-roadblock activity of the… CONTINUE READING
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