Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression.

@article{Zhang2007TranscriptionTF,
  title={Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression.},
  author={Zhiqiang Zhang and Alicia Klatt and Andrew J. Henderson and David S Gilmour},
  journal={Genes & development},
  year={2007},
  volume={21 13},
  pages={1609-14}
}
Many elongation factors in eukaryotes promote gene expression by increasing the processivity of RNA polymerase II (Pol II). However, the stability of RNA Pol II elongation complexes suggests that such complexes are not inherently prone to prematurely terminating transcription, particularly at physiological nucleotide concentrations. We show that the termination factor, Pcf11, causes premature termination on an HIV provirus. The transcription that occurs when Pcf11 is depleted from cells or an… CONTINUE READING

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