Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.

@article{Thiebaut2006TranscriptionTA,
  title={Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.},
  author={Marilyne Thiebaut and Elena Kisseleva-Romanova and Mathieu Rougemaille and Jocelyne Boulay and Domenico Libri},
  journal={Molecular cell},
  year={2006},
  volume={23 6},
  pages={
          853-64
        }
}
Cryptic unstable transcripts (CUTs) are widely distributed in the genome of S. cerevisiae. These RNAs generally derive from nonannotated regions of the genome and are degraded rapidly and efficiently by the nuclear exosome via a pathway that involves degradative polyadenylation by a new poly(A) polymerase borne by the TRAMP complex. What is the share of significant information that is encrypted in CUTs and what distinguishes a CUT from other Pol II transcripts are unclear to date. Here we… CONTINUE READING

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