Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.

  title={Transcription termination and nuclear degradation of cryptic unstable transcripts: a role for the nrd1-nab3 pathway in genome surveillance.},
  author={Marilyne Thiebaut and Elena Kisseleva-Romanova and Mathieu Rougemaille and Jocelyne Boulay and Domenico Libri},
  journal={Molecular cell},
  volume={23 6},

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The Exosome Component Rrp6 Is Required for RNA Polymerase II Termination at Specific Targets of the Nrd1-Nab3 Pathway

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The yeast RPL9B gene is regulated by modulation between two modes of transcription termination

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Accumulation of unstable promoter-associated transcripts upon loss of the nuclear exosome subunit Rrp6p in Saccharomyces cerevisiae.

  • C. DavisM. Ares
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2006
It is hypothesize that these transcripts reflect important features of RNA polymerase activity at the promoter that are normally undetectable in wild-type cells because the transcripts are somehow distinguished from true mRNAs and are degraded in an Rrp6p-dependent fashion in the nucleus.

cis- and trans-Acting Determinants of Transcription Termination by Yeast RNA Polymerase II

It is shown that the terminator elements for two yeast snoRNA genes also direct polyadenylated 3′-end formation in the context of an mRNA 3′ untranslated region, and that the termination signal is transduced through the Rpb3/Rpb11 heterodimer.

Identification of cis Elements Directing Termination of Yeast Nonpolyadenylated snoRNA Transcripts

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Interactions between mRNA Export Commitment, 3′-End Quality Control, and Nuclear Degradation

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