Transcription termination and anti‐termination in E. coli
@article{Nudler2002TranscriptionTA, title={Transcription termination and anti‐termination in E. coli}, author={Evgeny Nudler and Max E. Gottesman}, journal={Genes to Cells}, year={2002}, volume={7} }
Transcription termination in Escherichia coli is controlled by many factors. The sequence of the DNA template, the structure of the transcript, and the actions of auxiliary proteins all play a role in determining the efficiency of the process. Termination is regulated and can be enhanced or suppressed by host and phage proteins. This complex reaction is rapidly yielding to biochemical and structural analysis of the interacting factors. Below we review and attempt to unify into basic principles…
215 Citations
The role of E. coli Nus-Factors in transcription regulation and transcription
- BiologyTranscription
- 2011
The structural interplay and the mechanistic role of the Nus-factors that are directly involved in processive elongation, transcription:translation coupling and termination as well as the varying effects of these proteins on transcription under the influence of additional signals are discussed.
Control of Transcription Termination and Antitermination
- Biology
- 2005
The regulatory molecules that are known to influence the elongation/termination decision by RNA polymerase (RNAP) are described, with the emphasis on the most recent findings and on the mechanism of ‘‘active’’ regulators whose actions are not limited to changes in RNA folding.
Transcription termination by nuclear RNA polymerases.
- BiologyGenes & development
- 2009
The present state of knowledge on how each of the three RNA polymerases terminates and how mechanisms are conserved, or vary, from yeast to human is described.
Suppression of Factor-Dependent TranscriptionTermination by AntiterminatorRNA
- BiologyJournal of bacteriology
- 2003
Nascent transcripts of the phage HK022 put sites modify the transcription elongation complex so that it terminates less efficiently at intrinsic transcription terminators and accelerates through pause sites, suggesting that put inhibits a step that is common to termination at the different types of terminator.
Regulation of Transcription Elongation and Termination
- BiologyBiomolecules
- 2015
Why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect elongation and termination in E. coli are discussed.
Mechanism of Action of Bacterial Transcription Terminator Rho
- BiologyProceedings of the Indian National Science Academy
- 2018
This review includes the biochemistry and the structural analyses of the Rho, its mechanism of action, its regulation by other cellular factors and briefly cellular events controlled by this protein.
In vivo regulation of bacterial Rho-dependent transcription termination by the nascent RNA.
- BiologyThe Journal of biological chemistry
- 2022
Analysis of the intrinsic transcription termination mechanism and its control.
- BiologyMethods in enzymology
- 2003
References
SHOWING 1-10 OF 168 REFERENCES
nusA protein of Escherichia coli is an efficient transcription termination factor for certain terminator sites.
- BiologyJournal of molecular biology
- 1987
Mechanism of intrinsic transcription termination and antitermination.
- BiologyScience
- 1999
A transcription antiterminator inhibits this activity of oligonucleotides and therefore protects the elongation complex from destabilizing attacks on the emerging transcript.
The nus mutations affect transcription termination in Escherichia coli
- BiologyNature
- 1981
Observations suggest that the nusA and nusB gene products may act as termination factors analgous to rho protein in Escherichia coli and enhance transcription termination atphage termination sites.
Early transcribed sequences affect termination efficiency of Escherichia coli RNA polymerase.
- BiologyJournal of molecular biology
- 1989
Regulation of rho-dependent transcription termination by NusG is specific to the Escherichia coli elongation complex.
- BiologyBiochemistry
- 2000
It is concluded that NusG modulates Rho-dependent termination by interacting specifically with the RNAP of the E. coli elongation complex to render the complex more susceptible to the termination activity of Rho.
The remarkable specificity of a new transcription termination factor suggests that the mechanisms of termination and antitermination are similar
- BiologyCell
- 1987
Structural Organization of Transcription Termination Factor Rho (*)
- Biology, ChemistryThe Journal of Biological Chemistry
- 1996
The current understanding of the structure and function of transcription termination factor Rho is summarized based on indirect approaches, such as biochemical characterization of the protein, phylogenetic comparative analyses, and the functional properties of mutants with known amino acid changes.