Transcription-targeted DNA deamination by the AID antibody diversification enzyme

@article{Chaudhuri2003TranscriptiontargetedDD,
  title={Transcription-targeted DNA deamination by the AID antibody diversification enzyme},
  author={J. Chaudhuri and M. Tian and Chan Khuong and K. Chua and E. Pinaud and F. Alt},
  journal={Nature},
  year={2003},
  volume={422},
  pages={726-730}
}
Activation-induced cytidine deaminase (AID), which is specific to B lymphocytes, is required for class switch recombination (CSR)—a process mediating isotype switching of immunoglobulin—and somatic hypermutation—the introduction of many point mutations into the immunoglobulin variable region genes. It has been suggested that AID may function as an RNA-editing enzyme or as a cytidine deaminase on DNA. However, the precise enzymatic activity of AID has not been assessed in previous studies… Expand
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