Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells.

@article{Sugawara2002TranscriptionSO,
  title={Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells.},
  author={Akira Sugawara and Akira Uruno and Masataka Kudo and Yukio Ikeda and Kazunori Sato and Yoshihiro Taniyama and Sadayoshi Ito and Kazuhisa Takeuchi},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 12},
  pages={9676-83}
}
Thromboxane (TX) A(2) exerts contraction and proliferation of vascular smooth muscle cells (VSMCs) via its specific membrane TX receptor (TXR), possibly leading to the progression of atherosclerosis. A nuclear hormone receptor, peroxisome proliferator-activated receptor (PPAR)-gamma, has recently been reported to be expressed in VSMCs. Here we examined a role of PPAR-gamma in TXR gene expression in VSMCs. PPAR-gamma ligands 15-deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone reduced TXR… CONTINUE READING
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