Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON.

@article{Sun2001TranscriptionRO,
  title={Transcription repression of human hepatitis B virus genes by negative regulatory element-binding protein/SON.},
  author={Chia-Wei Sun and W Y Lo and Ida Hsiao Yun Wang and Yuet H Lo and S R Shiou and C. K. W. Lai and L P Ting},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 26},
  pages={24059-67}
}
A negative regulatory element (NRE) is located immediately upstream of the upstream regulatory sequence of core promoter and second enhancer of human hepatitis B virus (HBV). NRE represses the transcription activation function of the upstream regulatory sequence of core promoter and the second enhancer. In this study, we described the cloning and characterization of an NRE-binding protein (NREBP) through expression cloning. NREBP cDNA is 8266 nucleotides in size and encodes a protein of 2386… CONTINUE READING