Transcription-replication encounters, consequences and genomic instability

  title={Transcription-replication encounters, consequences and genomic instability},
  author={Anne Helmrich and Monica Ballarino and Vladimir Svetlov and L{\'a}szl{\'o} Tora},
  journal={Nature Structural &Molecular Biology},
To ensure accurate duplication of genetic material, the replication fork must overcome numerous natural obstacles on its way, including transcription complexes engaged along the same template. Here we review the various levels of interdependence between transcription and replication processes and how different types of encounters between RNA- and DNA-polymerase complexes may result in clashes of those machineries on the DNA template and thus increase genomic instability. In addition, we… CONTINUE READING