Transcription regulation of the vegf gene by the BMP/Smad pathway in the angioblast of zebrafish embryos.

@article{He2005TranscriptionRO,
  title={Transcription regulation of the vegf gene by the BMP/Smad pathway in the angioblast of zebrafish embryos.},
  author={Chen He and Xiaozhuo Chen},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={329 1},
  pages={324-30}
}
Vascular endothelial growth factor (VEGF) is a mitogen that is critically involved in vasculogenesis, angiogenesis, and hematopoiesis. However, what and how transcription factors participate in the regulation of vegf gene expression are not fully understood. Here we report the cloning and sequencing of the zebrafish vegf promoter which revealed that the promoter contains a number of bone morphogenetic protein (BMP)-activated Smad binding elements (SBE), implicating Smad1 and Smad5 in the… CONTINUE READING

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