Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between drosophila and humans.

@article{Vijh2002TranscriptionRO,
  title={Transcription regulation of human chemokine receptor CCR3: evidence for a rare TATA-less promoter structure conserved between drosophila and humans.},
  author={Sujata Vijh and Debora E. Dayhoff and Carol E. Wang and Zakaria Imam and Philip K. Ehrenberg and Nelson L Michael},
  journal={Genomics},
  year={2002},
  volume={80 1},
  pages={86-95}
}
The chemokine receptor CCR3 has a critical function in the pathogenesis of eosinophilic diseases and is an entry co-receptor for HIV-1. We describe here the genomic organization and general transcriptional control mechanism for the human gene CCR3. We identified six cDNA transcripts formed by alternative splicing of eight exons and seven introns. CCR3 contains a 37-bp core promoter domain (-3 to +34 relative to the transcription start point) lacking a TATA box but inclusive of an initiator… CONTINUE READING

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