Transcription profiling of Prss16 (Tssp) can be used to find additional peptidase genes that are candidates for self-peptide generation in the thymus

@article{Fornari2011TranscriptionPO,
  title={Transcription profiling of Prss16 (Tssp) can be used to find additional peptidase genes that are candidates for self-peptide generation in the thymus},
  author={Tha{\'i}s Arouca Fornari and M{\'a}rcia M. C. Marques and Catherine Nguyen and Alice Carrier and Geraldo A. S. Passos},
  journal={Molecular Biology Reports},
  year={2011},
  volume={39},
  pages={4051-4058}
}
Positive selection (PS) in the thymus involves the presentation of self-peptides that are bound to MHC class II on the surface of cortical thymus epithelial cells (cTECs). Prss16 gene corresponds to one important element regulating the PS of CD4+ T lymphocytes, which encodes Thymus-specific serine protease (Tssp), a cTEC serine-type peptidase involved in the proteolytic generation of self-peptides. Nevertheless, additional peptidase genes participating in the generation of self-peptides need to… CONTINUE READING
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