Transcription of vesicular stomatitis virus activated by pardaxin, a fish toxin that permeabilizes the virion membrane.

Abstract

The toxic protein, Pardaxin, of the Red Sea flatfish Pardachirus marmoratus readily induced transcription of vesicular stomatitis virus by making the virion membrane permeable to nucleoside triphosphates in the absence of nonionic detergents. Virion transcription was activated over a wide range of Pardaxin concentrations, but at optimal concentrations, the… (More)

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