Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix.

@article{Wessel1989TranscriptionOT,
  title={Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix.},
  author={Gary M Wessel and Wen-xiang Zhang and Craig R. Tomlinson and William J. Lennarz and William H. Klein},
  journal={Development},
  year={1989},
  volume={106 2},
  pages={355-65}
}
The influence of the extracellular matrix (ECM) on differential gene expression during sea urchin development was explored using cell-type-specific cDNA probes. The ECM of three species of sea urchin, Strongylocentrotus purpuratus, Lytechinus variegatus and Lytechinus pictus, was disrupted with the lathrytic agent beta-aminopropionitrile (BAPN), which inhibits collagen deposition in the ECM and arrests gastrulation (Wessel & McClay, Devl Biol. 121: 149, 1987). The levels of several mRNAs (Spec… CONTINUE READING

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