Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences

@article{Liu2002TranscriptionOT,
  title={Transcription of the Drosophila CKI gene dacapo is regulated by a modular array of cis-regulatory sequences},
  author={T Liu and Ling Li and Harald Vaessin},
  journal={Mechanisms of Development},
  year={2002},
  volume={112},
  pages={25-36}
}
Organogenesis requires coordination between developmental programs and cell cycle progression. The Cip/Kip families of cyclin-dependent kinase inhibitor (CKI) are main effectors linking these two programs. In many instances, expression of Cip/Kip CKIs are increased abruptly in cells entering their last mitotic cycle, suggesting that CKI expression is developmentally regulated. Expression of Dacapo (Dap), a Drosophila Cip/Kip CKI, is transiently up-regulated immediately before cells enter G1… CONTINUE READING
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