Transcription of N-myc and proliferation-related genes is linked in human neuroblastoma.


A definite association between the transcription of N-myc oncogene and proliferation-related genes, histone H3, c-myc and p53, was found in a set of 12 primary untreated neuroblastomas and a metastasis of one of these at relapse. Molecular analysis allowed us to discriminate between actually proliferating and non-proliferating tumors, and suggested a link between N-myc and proliferation. Flow cytometric analysis of DNA distribution was less reliable for assessing tumor proliferative activity. Our data also seem to indicate a down-regulation of c-myc by N-myc in human neuroblastoma.


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@article{Raschell1991TranscriptionON, title={Transcription of N-myc and proliferation-related genes is linked in human neuroblastoma.}, author={Giuseppe Raschell{\`a} and Anna Negroni and Cesare Giubilei and Annette Romeo and Se. Ferrari and Manuel A. Castello and Carlo Dominici}, journal={Cancer letters}, year={1991}, volume={56 1}, pages={45-51} }