Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease

@inproceedings{Jundi2015TranscriptionOI,
  title={Transcription of Interleukin-8: How Altered Regulation Can Affect Cystic Fibrosis Lung Disease},
  author={Karim Jundi and Catherine M Greene and Ivana Van{\vc}urov{\'a}},
  booktitle={Biomolecules},
  year={2015}
}
Interleukin-8 (IL-8) is a neutrophil chemokine that is encoded on the CXCL8 gene. Normally CXCL8 expression is repressed due to histone deacetylation, octamer-1 binding to the promoter and the inhibitory effect of nuclear factor-κB repressing factor (NRF). However, in response to a suitable stimulus, the human CXCL8 gene undergoes transcription due to its… CONTINUE READING