Transcription-independent functions of MYC: regulation of translation and DNA replication

  title={Transcription-independent functions of MYC: regulation of translation and DNA replication},
  author={Michael D. Cole and Victoria Haigh Cowling},
  journal={Nature Reviews Molecular Cell Biology},
MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating… CONTINUE READING