Transcription-generated torsional stress destabilizes nucleosomes

  title={Transcription-generated torsional stress destabilizes nucleosomes},
  author={Sheila S Teves and Steven Henikoff},
  booktitle={Nature Structural &Molecular Biology},
As RNA polymerase II (Pol II) transcribes a gene, it encounters an array of well-ordered nucleosomes. How it traverses through this array in vivo remains unresolved. One model proposes that torsional stress generated during transcription destabilizes nucleosomes ahead of Pol II. Here, we describe a method for high-resolution mapping of underwound DNA, using next-generation sequencing, and show that torsion is correlated with gene expression in Drosophila melanogaster cells. Accumulation of… CONTINUE READING
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