Transcription factors as targets of anticancer drugs.

  title={Transcription factors as targets of anticancer drugs.},
  author={Marek Gniazdowski and Malgorzata Czyz},
  journal={Acta biochimica Polonica},
  volume={46 2},
Several general and gene- and cell-selective transcription factors are required for specific transcription to occur. Many of them exert their functions through specific contacts either in the promoter region or at distant sequences regulating the initiation. These contacts may be altered by anticancer drugs which form non-covalent complexes with DNA. Covalent modifications of DNA by alkylating agents may prevent transcription factors from recognizing their specific sequences or may constitute… CONTINUE READING