Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development.

@article{CohenSolal2018TranscriptionFA,
  title={Transcription factors as critical players in melanoma invasiveness, drug resistance, and opportunities for therapeutic drug development.},
  author={Karine A Cohen-Solal and Howard L. Kaufman and Ahmed Lasfar},
  journal={Pigment cell & melanoma research},
  year={2018},
  volume={31 2},
  pages={241-252}
}
Resistance to targeted therapy in cancer is often coupled with the acquisition of a pro-invasive phenotype by tumors cells and a highly permissive tumor microenvironment promoting drug resistance. Transcription factors are frequently shown as major points of convergence of multiple dysregulated receptors and signaling pathways in cancer. Several transcription factors are now incriminated as drivers of both drug resistance and invasiveness. We focused this review on critical transcription… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.
0 Citations
71 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 71 references

Similar Papers

Loading similar papers…