Transcription factors and target genes of pre-TCR signaling

@article{LpezRodrguez2015TranscriptionFA,
  title={Transcription factors and target genes of pre-TCR signaling},
  author={Cristina L{\'o}pez-Rodr{\'i}guez and Jose Aramburu and Rosa Berga-Bola{\~n}os},
  journal={Cellular and Molecular Life Sciences},
  year={2015},
  volume={72},
  pages={2305-2321}
}
Almost 30 years ago pioneering work by the laboratories of Harald von Boehmer and Susumo Tonegawa provided the first indications that developing thymocytes could assemble a functional TCRβ chain-containing receptor complex, the pre-TCR, before TCRα expression. The discovery and study of the pre-TCR complex revealed paradigms of signaling pathways in control of cell survival and proliferation, and culminated in the recognition of the multifunctional nature of this receptor. As a receptor… CONTINUE READING

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