Transcription factors and neoplasia: vistas in novel drug design.

  title={Transcription factors and neoplasia: vistas in novel drug design.},
  author={Mihalis V Karamouzis and Vassilis G Gorgoulis and Athanasios G. Papavassiliou},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={8 5},
PURPOSE The fundamental role of gene transcription and the recognition of transcription factors as important control elements of cell growth, differentiation, and programmed cell death (apoptosis) aroused an ever-increasing interest for these proteins as potential pharmaceutical targets for therapeutic intervention in various diseases, among them cancer. EXPERIMENTAL DESIGN-RESULTS: The vast array of information available for their molecular architecture and mode of action in various biological… CONTINUE READING