Transcription factors T-bet and GATA-3 regulate development of airway remodeling.

  title={Transcription factors T-bet and GATA-3 regulate development of airway remodeling.},
  author={Takumi Kiwamoto and Yukio Ishii and Yuko Morishima and Keigyou Yoh and Atsuko Maeda and Kazusa Ishizaki and Takashi Iizuka and Ahmed E Hegab and Yosuke Matsuno and Shinsuke Homma and Akihiro Nomura and Tohru Sakamoto and Satoru Takahashi and Kiyohisa Sekizawa},
  journal={American journal of respiratory and critical care medicine},
  volume={174 2},
RATIONALE Airway remodeling is an important feature of chronic asthma that causes irreversible airflow obstruction. Although asthma is considered to be a Th2 disease, the role of T-bet and GATA-3, the key transcription factors for differentiation toward Th1 and Th2 cells, in the pathogenesis of airway remodeling is poorly understood. OBJECTIVES We therefore examined the effects of GATA-3 or T-bet induction of Th1/Th2 bias on the development of airway remodeling in mice. METHODS The… CONTINUE READING