Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I

@article{Shin2017TranscriptionFS,
  title={Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I},
  author={Yong-hyun Shin and Yu Tang Ren and Hitomi Suzuki and Kayla Golnoski and Hyo Won Ahn and Vasil Mico and Aleksandar Rajkovic},
  journal={Journal of Clinical Investigation},
  year={2017},
  volume={127},
  pages={2106–2117}
}
Following migration of primordial germ cells to the genital ridge, oogonia undergo several rounds of mitotic division and enter meiosis at approximately E13.5. Most oocytes arrest in the dictyate (diplotene) stage of meiosis circa E18.5. The genes necessary to drive oocyte differentiation in parallel with meiosis are unknown. Here, we have investigated whether expression of spermatogenesis and oogenesis bHLH transcription factor 1 (Sohlh1) and Sohlh2 coordinates oocyte differentiation within… CONTINUE READING
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