Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II

@article{Goodrich1994TranscriptionFI,
  title={Transcription factors IIE and IIH and ATP hydrolysis direct promoter clearance by RNA polymerase II},
  author={J. Goodrich and R. Tjian},
  journal={Cell},
  year={1994},
  volume={77},
  pages={145-156}
}
  • J. Goodrich, R. Tjian
  • Published 1994
  • Biology, Medicine
  • Cell
  • Using a defined RNA polymerase II (pol II) transcription system, we have investigated the roles of basal factors at discrete stages during the transcription cycle (e.g., initiation, promoter clearance, and transcript elongation). Abortive initiation assays revealed that TATA-binding protein, transcription factors TFIIB and TFIIF, and pol II were necessary and sufficient to form functional initiation complexes on both linear and supercoiled templates. By contrast, TFIIE, TFIIH, and ATP… CONTINUE READING

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