Transcription factors, chromatin and cancer.

  title={Transcription factors, chromatin and cancer.},
  author={James L Thorne and Moray J. Campbell and Bryan M. Turner},
  journal={The international journal of biochemistry & cell biology},
  volume={41 1},
Transcription factors, chromatin and chromatin-modifying enzymes are key components in a complex network through which the genome interacts with its environment. For many transcription factors, binding motifs are found adjacent to the promoter regions of a large proportion of genes, requiring mechanisms that confer binding specificity in any given cell type. These include association of the factor with other proteins and packaging of DNA, as chromatin, at the binding sequence so as to inhibit… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 19 extracted citations

Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.

Cancer cell • 2018
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 171 references

FoxA 1 translates epigenetic signatures into enhancerdriven lineagespecific transcription

B ateescu, P England, F Halgand, M Yaniv, C Muchardt
Cell • 2008

Genomic analysis of estrogen cascade reveals histone variant H 2 A . Z associatedwith breast cancer progression

KD uynh, VJ Bardwell
Mol Syst Biol • 2008

Similar Papers

Loading similar papers…