Transcription factors, chromatin and cancer.

@article{Thorne2009TranscriptionFC,
  title={Transcription factors, chromatin and cancer.},
  author={James L Thorne and Moray J. Campbell and Bryan M. Turner},
  journal={The international journal of biochemistry & cell biology},
  year={2009},
  volume={41 1},
  pages={164-75}
}
Transcription factors, chromatin and chromatin-modifying enzymes are key components in a complex network through which the genome interacts with its environment. For many transcription factors, binding motifs are found adjacent to the promoter regions of a large proportion of genes, requiring mechanisms that confer binding specificity in any given cell type. These include association of the factor with other proteins and packaging of DNA, as chromatin, at the binding sequence so as to inhibit… CONTINUE READING

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