Transcription factories and nuclear organization of the genome.

  title={Transcription factories and nuclear organization of the genome.},
  author={Christopher H. Eskiw and Nathan F. Cope and Ieuan Clay and Stefan Schoenfelder and Takashi Nagano and Peter Fraser},
  journal={Cold Spring Harbor symposia on quantitative biology},
The dynamic compartmental organization of the transcriptional machinery in mammalian nuclei places particular constraints on the spatial organization of the genome. The clustering of active RNA polymerase I transcription units from several chromosomes at nucleoli is probably the best-characterized and universally accepted example. RNA polymerase II localization in mammalian nuclei occurs in distinct concentrated foci that are several-fold fewer in number compared to the number of active genes… CONTINUE READING

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