Transcription factories: gene expression in unions?

  title={Transcription factories: gene expression in unions?},
  author={Heidi G.E. Sutherland and Wendy A. Bickmore},
  journal={Nature Reviews Genetics},
Transcription is a fundamental step in gene expression, yet it remains poorly understood at a cellular level. Visualization of transcription sites and active genes has led to the suggestion that transcription occurs at discrete sites in the nucleus, termed transcription factories, where multiple active RNA polymerases are concentrated and anchored to a nuclear substructure. However, this concept is not universally accepted. This Review discusses the experimental evidence in support of the… CONTINUE READING