Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.

@article{Sobue2005TranscriptionFS,
  title={Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12.},
  author={Satoshi Sobue and Kazumi Hagiwara and Y. Banno and Keiko Tamiya-Koizumi and Motoshi Suzuki and Akira P Takagi and Tetsuhito Kojima and Haruhiko Asano and Yoshinori Nozawa and Takashi Murate},
  journal={Journal of neurochemistry},
  year={2005},
  volume={95 4},
  pages={940-9}
}
Sphingosine kinase (SPHK) is known to exert an anti-apoptic role in various cells and cell lines. We previously reported that human brain is rich in SPHK1 (Murate et al. 2001). After showing a high expression of SPHK1 in rat brain, we examined the gene expression mechanism using nerve growth factor (NGF)-stimulated rat PC12 cells. With RT-PCR, we found that both rat brain and PC12 utilized exon 1d mostly out of eight untranslated first exons. NGF induced an increase in SPHK enzyme activity and… CONTINUE READING

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