Transcription factor regulation as a mechanism of confounding effects between distinct human traits

@article{Pjanic2015TranscriptionFR,
  title={Transcription factor regulation as a mechanism of confounding effects between distinct human traits},
  author={M. Pjanic and Clint L. Miller and T. Quertermous},
  journal={F1000Research},
  year={2015},
  volume={4},
  pages={1349}
}
  • M. Pjanic, Clint L. Miller, T. Quertermous
  • Published 2015
  • Medicine
  • F1000Research
  • Genome-wide association studies (GWAS) to date have discovered thousands of genetic variants linked to human diseases and traits, which hold the potential to unravel the mechanisms of complex phenotypes. However, given that the majority of these associated variants reside in non-coding genomic regions, their predicted cis and trans -regulatory functions remain largely undefined. Here we show that correlation between human diseases and traits can follow geographical distribution of human… CONTINUE READING

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