Transcription factor network in embryonic stem cells: heterogeneity under the stringency.

@article{NakaiFutatsugi2013TranscriptionFN,
  title={Transcription factor network in embryonic stem cells: heterogeneity under the stringency.},
  author={Yoko Nakai-Futatsugi and Hitoshi Niwa},
  journal={Biological & pharmaceutical bulletin},
  year={2013},
  volume={36 2},
  pages={166-70}
}
Leukemia inhibitory factor (LIF) signaling regulates transcription factors to maintain the self-renewability and pluripotency of embryonic stem (ES) cells. Recently, we have proposed a network model that consists of transcription factors such as, Klf4, Sox2, Tbx3, Nanog, and Oct3/4, which form a parallel pathway downstream from LIF signaling (Nature, 460, 2009, Niwa et al.). In this parallel pathway, the transcription factors maintain the pluripotency of ES cells through mutual balance with… CONTINUE READING