Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.

@article{TorresPadilla2014TranscriptionFH,
  title={Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.},
  author={Maria-Elena Torres-Padilla and Ian Chambers},
  journal={Development},
  year={2014},
  volume={141 11},
  pages={2173-81}
}
When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here using Nanog, a key regulator of pluripotency, as a model gene. We discuss the role… CONTINUE READING
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