Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages.

@article{Mendoza2013TranscriptionFE,
  title={Transcription factor evolution in eukaryotes and the assembly of the regulatory toolkit in multicellular lineages.},
  author={Alex de Mendoza and Arnau Seb{\'e}-Pedr{\'o}s and Martin Sebastijan {\vS}estak and Marija Matej{\vc}i{\'c} and Guifr{\'e} Torruella and Tomislav Domazet-Lo{\vs}o and I{\~n}aki Ruiz-Trillo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 50},
  pages={E4858-66}
}
Transcription factors (TFs) are the main players in transcriptional regulation in eukaryotes. However, it remains unclear what role TFs played in the origin of all of the different eukaryotic multicellular lineages. In this paper, we explore how the origin of TF repertoires shaped eukaryotic evolution and, in particular, their role into the emergence of multicellular lineages. We traced the origin and expansion of all known TFs through the eukaryotic tree of life, using the broadest possible… CONTINUE READING

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