Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites.

@article{Borgatti2003TranscriptionFD,
  title={Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites.},
  author={Monica Borgatti and Ilaria Lampronti and Alessandra Romanelli and Carlo Pedone and Michele Saviano and Nicoletta Bianchi and Carlo Mischiati and Roberto Gambari},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 9},
  pages={7500-9}
}
Peptide nucleic acids (PNAs) are DNA-mimicking molecules in which the sugar-phosphate backbone is replaced by a pseudopeptide backbone composed of N-(2-aminoethyl)glycine units. We determined whether double-stranded molecules based on PNAs and PNA-DNA-PNA (PDP) chimeras could be capable of stable interactions with nuclear proteins belonging to the Sp1 transcription factor family and, therefore, could act as decoy reagents able to inhibit molecular interactions between Sp1 and DNA. Since the… CONTINUE READING

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Sp1 Proteins to PNA-DNA Chimeras 7509 by gest on N ovem er 8, 2017 hp://w w w .jb.org/ D

M. Borgatti, L. Breda, +7 authors R. Gambari
November 20, • 2002

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