Transcription factor binding dynamics during human ESC differentiation

  title={Transcription factor binding dynamics during human ESC differentiation},
  author={Alexander M. Tsankov and Hongcang Gu and Veronika Akopian and Michael J. Ziller and Julie A Donaghey and Ido Amit and Andreas Gnirke and Alexander Meissner},
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors with extensive epigenome and transcriptional data across the differentiation of human embryonic stem cells to the three germ layers. We describe core regulatory dynamics and show the lineage-specific behaviour of selected factors. In addition to… CONTINUE READING

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