Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension.

@article{Feng2015TranscriptionFA,
  title={Transcription factor avian erythroblastosis virus E26 oncogen homolog-1 is a novel mediator of renal injury in salt-sensitive hypertension.},
  author={Wenguang Feng and Phillip H Chumley and Minolfa C. Prieto and Kayoko Miyada and Dale M. Seth and Huma Fatima and Ping Hua and Gabriel Rezonzew and Paul W. Sanders and Edgar A. Jaimes},
  journal={Hypertension},
  year={2015},
  volume={65 4},
  pages={813-20}
}
Transcription factor E26 transformation-specific sequence-1 (ETS-1) is a transcription factor that regulates the expression of a variety of genes, including growth factors, chemokines, and adhesion molecules. We recently demonstrated that angiotensin II increases the glomerular expression of ETS-1 and that blockade of ETS-1 ameliorates the profibrotic and proinflammatory effects of angiotensin II. The Dahl salt-sensitive rat is a paradigm of salt-sensitive hypertension associated with local… CONTINUE READING
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