Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.

@article{Wu2016TranscriptionFZ,
  title={Transcription factor Zeb2 regulates commitment to plasmacytoid dendritic cell and monocyte fate.},
  author={Xiaodi Wu and Carlos Mario Garcidue{\~n}as Brise{\~n}o and Gary E. Grajales-Reyes and Malay Haldar and Arifumi Iwata and Nicole M. Kretzer and Wumesh Kc and Roxane Tussiwand and Yujiro Higashi and Theresa L Murphy and Kenneth M Murphy},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 51},
  pages={
          14775-14780
        }
}
Dendritic cells (DCs) and monocytes develop from a series of bone-marrow-resident progenitors in which lineage potential is regulated by distinct transcription factors. Zeb2 is an E-box-binding protein associated with epithelial-mesenchymal transition and is widely expressed among hematopoietic lineages. Previously, we observed that Zeb2 expression is differentially regulated in progenitors committed to classical DC (cDC) subsets in vivo. Using systems for inducible gene deletion, we uncover a… CONTINUE READING
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