Transcription factor YY1 expression in human gastrointestinal cancer cells.

  title={Transcription factor YY1 expression in human gastrointestinal cancer cells.},
  author={Dharmaraj Chinnappan and Dongmei Xiao and Anita Ratnasari and Chris Andry and Thomas Christopher King and Horst Christian Weber},
  journal={International journal of oncology},
  volume={34 5},
Over-expression of the multifunctional zinc-finger transcription factor Yin Yang 1 (YY1) has been associated with cellular proliferation and resistance to apoptotic stimuli. In this study, we report that YY1 was uniformly highly over-expressed in a wide range of human cancer cell lines and in human colon cancer tissue samples. The examination of YY1-specific mRNA expression demonstrated at least six mRNA isoforms ubiquitously expressed in normal human adult and fetal tissues. Substantial over… CONTINUE READING
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