Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells.

@article{Lu2012TranscriptionFT,
  title={Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells.},
  author={Rong Lu and Yangluowa Qu and Jian Ge and Lili Zhang and Zhitao Su and Stephen Carl Pflugfelder and De-quan Li},
  journal={Stem cells},
  year={2012},
  volume={30 4},
  pages={
          753-61
        }
}
TCF4, a key transcription factor of Wnt signaling system, has been recently found to be essential for maintaining stem cells. However, its signaling pathway is not well elucidated. This study was to explore the functional roles and signaling pathway of TCF4 in maintaining adult stem cell properties using human corneal epithelial stem cells as a model. With immunofluorescent staining and real-time polymerase chain reaction, we observed that TCF4 was exclusively expressed in the basal layer of… CONTINUE READING
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